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TAK-715

A potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM; displays >20-fold selectvity over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1; inhibits LPS-stimulated release of TNF-alpha from THP-1 with IC50 of 48 nM; exerts significant efficacy in rat adjuvant-induced arthritis model.Rheumatoid Arthritis Phase 2 Discontinued.

Product Specifications

CAS Number

303162-79-0

Product Name Alternative

TAK 715 | TAK715

Field of Research

Epigenetics & Chromatin

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

O=C (NC1=NC=CC (C2=C (C3=CC=CC (C) =C3) N=C (CC) S2) =C1) C4=CC=CC=C4

Molecular Formula

C24H21N3OS

Molecular Weight

399.508

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Benzamide, N-[4-[2-ethyl-4- (3-methylphenyl) -5-thiazolyl]-2-pyridinyl]-

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