SMER-28
A small-molecule enhancer/inducer of Autophagy; decreases the levels of Aβ peptide (EC50=10 uM) and APP-CTF (EC50 of 20 uM) in a γ-secretase-independent manner in primary neuronal cultures, Atg5, Beclin1 and Ulk1 are shown to be involved in the degradation of Aβ and APP-CTF; enhances erythropoiesis in a range of in vitro and in vivo models of DBA, and protects against neurodegeneration in Drosophila model of Huntington’s disease.
Product Specifications
CAS Number
307538-42-7
Product Name Alternative
SMER28
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
C=CCNC1=C2C=C (Br) C=CC2=NC=N1
Molecular Formula
C11H10BrN3
Molecular Weight
264.1212
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-Quinazolinamine, 6-bromo-N-2-propen-1-yl-
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