M2I-1
The first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20; equally potent in inhibiting the binding of F-Mbp1 to Mad2; disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20, weakens the spindle assembly checkpoint (SAC) response.
Product Specifications
CAS Number
312271-03-7
Product Name Alternative
Mad2 inhibitor 1
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
O=C (/C (C (N1) =O) =C\C2=CC=C (N (CC (C) C) CC (C) C) C ([N+] ([O-]) =O) =C2) NC1=S
Molecular Formula
C19H24N4O4S
Molecular Weight
404.4832
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4,6 (1H,5H) -Pyrimidinedione, 5-[[4-[bis (2-methylpropyl) amino]-3-nitrophenyl]methylene]dihydro-2-thioxo-
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