JK184
JK184 is an ntagonist of the hedgehog (Hh) signaling pathway and Gli inhibitor; inhibits GLI1 mRNA expression and decreases the number of colonies formed in TN-IBC (SUM149) and TNBC (MDA-MB-231 and SUM159) cell lines; significantly down-regulates GLI1 targets that regulate cell cycle (cyclin D and E) and apoptosis (Bcl2) ; JK184 is a potent inhibitor of microtubule assembly and that microtubule-depolymerizing agents can either negatively or positively regulate the Gli family of transcription factors, dependending on the mechanism by which the pathway is activated.
Product Specifications
CAS Number
315703-52-7
Product Name Alternative
JK-184 | JK 184
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC1=C (C2=CSC (NC3=CC=C (OCC) C=C3) =N2) N4C=CC=CC4=N1
Molecular Formula
C19H18N4OS
Molecular Weight
350.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Thiazolamine, N- (4-ethoxyphenyl) -4- (2-methylimidazo[1,2-a]pyridin-3-yl) -
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