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Monastrol (b)

A potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition) ; does not inhibit microtubule motility driven by conventional kinesin at 200 uM; inhibits both the basal and the microtubule-stimulated ATPase activity of the Eg5 motor domain, does not compete with ATP binding to Eg5; arrests cells in mitosis with monoastral spindles, and (S) -monastrol is a more potent inhibitor of Eg5 activity in vitro and in vivo.

Product Specifications

CAS Number

329689-23-8

Product Name Alternative

±) -Monastrol

Purity

>98% (HPLC)

Solubility

DMSO: ≥ 33 mg/mL

Smiles

CCOC (=O) C1=C (NC (=S) NC1C2=CC (=CC=C2) O) C

Molecular Formula

C14H16N2O3S

Molecular Weight

292.35344

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4- (3-hydroxyphenyl) -6-methyl-2-thioxo-, ethyl ester

Available Sizes

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