AK-1
A potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 12.5 uM; induces proteasomal degradation of the Snail transcription factor through inactivation of the NF-κB/CSN2 pathway; increases the ubiquitination of HIF-1α in a VHL-dependent manner, leading to the degradation of HIF-1α via a proteasomal pathway.
Product Specifications
CAS Number
330461-64-8
Product Name Alternative
DA-42784 | KB-120200 | DA42784 | KB120200 | J018989 | DA 42784 | KB 120200 | J 018989
Field of Research
Signal Transduction
Purity
>98% (HPLC)
Solubility
DMSO
Smiles
O=C (NC1=CC=CC ([N+] ([O-]) =O) =C1) C2=CC=CC (S (=O) (N3CCCCCC3) =O) =C2
Molecular Formula
C19H21N3O5S
Molecular Weight
403.45214
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, 3-[ (hexahydro-1H-azepin-1-yl) sulfonyl]-N- (3-nitrophenyl) -
Available Sizes
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