Nucleozin
A small-molecule influenza A nucleoprotein (NP) inhibitor that triggers the aggregation of NP and inhibits its nuclear accumulation; inhibits infection of MDCK cells by viruses influenza A/WSN/33, H3N2 (clinical isolate) and Vietnam/1194/04 (H5N1) with EC50 of 0.069 uM, 0.16 uM and 0.33 uM in PRA, respectively; protects mice challenged with lethal doses of avian influenza A H5N1; also targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection.Influenza Preclinical.
Product Specifications
CAS Number
341001-38-5
Product Name Alternative
Nucleozin
Purity
>98% (HPLC)
Solubility
DMSO: 28.66 mg/mL (Need ultrasonic)
Smiles
O=C (N1CCN (C2=CC=C ([N+] ([O-]) =O) C=C2Cl) CC1) C3=C (C) ON=C3C4=CC=CC=C4
Molecular Formula
C21H19ClN4O4
Molecular Weight
426.853
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Methanone, [4- (2-chloro-4-nitrophenyl) -1-piperazinyl] (5-methyl-3-phenyl-4-isoxazolyl) -
Available Sizes
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