Leukadherin 1
Leukadherin 1 (LA1) is a small molecule allosteric agonist of integrin CD11b/CD18 (CR3), increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50=4 uM) ; reduces IFN-I responses in WT but not CD11b-deficient mice, and protects lupus-prone MRL/Lpr mice from end-organ injury; reduces TLR-dependent proinflammatory signaling in leukocytes and suppresses IFN-I signaling via an AKT/FOXO3/IFN regulatory factor 3/7 pathway.
Product Specifications
CAS Number
344897-95-6
Product Name Alternative
LA1
Purity
>98% (HPLC)
Solubility
DMSO: 15 mg/mL (35.59 mM) ; Water: <1 mg/mL; Ethanol: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (O) C1=CC=C (C2=CC=C (/C=C (SC (N3CC4=CC=CC=C4) =S) /C3=O) O2) C=C1
Molecular Formula
C22H15NO4S2
Molecular Weight
421.49
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-[ (5-[[4-Oxo-3- (phenylmethyl) -2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]benzoic acid
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