Camptothecin-d5
Camptothecin-d5 is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].
Product Specifications
CAS Number
1329616-37-6
Product Name Alternative
Campathecin-d5; (S) - (+) -Camptothecin-d5; CPT-d5
UNSPSC
12352005
Target
ADC Payload; Antibiotic; Apoptosis; Fungal; Influenza Virus; Isotope-Labeled Compounds; MicroRNA; Topoisomerase
Type
Isotope-Labeled Compounds
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer; Infection
Purity
99.61
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])C([2H])([2H])[C@@]1(C2=C(COC1=O)C(N3C(C4=NC5=CC=CC=C5C=C4C3)=C2)=O)O
Molecular Formula
C20H11D5N2O4
Molecular Weight
353.38
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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