SZL P1-41
A small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro; specific diminishes E3-ligase activity of Skp2-SCF complex, but not of other F-box SCF complex; inhibits Skp2-mediated p27 ubiquitination, induced endogenous p27 protein expression in prostate cancer cells; exhibits potent antitumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival.
Product Specifications
CAS Number
222716-34-9
Product Name Alternative
SZL-P1-41 | SZL P1 41 | SZLP141 | SKP2 E3 Ligase Inhibitor III
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C1C (C2=NC3=CC=CC=C3S2) =COC4=C (CN5CCCCC5) C (O) =C (CC) C=C14
Molecular Formula
C24H24N2O3S
Molecular Weight
420.524
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4H-1-Benzopyran-4-one, 3- (2-benzothiazolyl) -6-ethyl-7-hydroxy-8- (1-piperidinylmethyl) -
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