Gefitinib-based PROTAC 3
Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R) .
Product Specifications
CAS Number
2230821-27-7
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 60 mg/mL64.20 mM
Smiles
CC1=C (SC=N1) C2=CC=C (C=C2) CNC (=O) C3CC (CN3C (=O) C (C (C) (C) C) NC (=O) CCOCCOCCCCCOC4=C (C=C5C (=C4) C (=NC=N5) NC6=CC (=C (C=C6) F) Cl) OC) O
Molecular Formula
C47H57ClFN7O8S
Molecular Weight
934.522
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2S,4R) -1- ((S) -2- (3- (2- ((5- ((4- ((3-chloro-4-fluorophenyl) amino) -7-methoxyquinazolin-6-yl) oxy) pentyl) oxy) ethoxy) propanamido) -3,3-dimethylbutanoyl) -4-hydroxy-N- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide
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