YM-58483
A store-operated Ca2+ entry blocker and CRAC channel inhibitor with IC50 of 100 nM; inhibits Ca (2+) influx through SOC channels without affecting the TCR signal transduction cascade in Jurkat cells, inhibits thapsigargin-induced sustained Ca (2+) influx (IC50=100 nM), and 30-fold less potent against Cav channels; potently inhibits IL-2 production and NF-AT-driven promoter activity in Jurkat cells; also inhibits IL-4 and IL-5 production Th2 T cells, prevents antigen-induced inflammatory responses in animal models; orally active.
Product Specifications
CAS Number
223499-30-7
Product Name Alternative
YM58483 | YM 58483 | BPT2
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
O=C (C1=C (C) N=NS1) NC2=CC=C (N3N=C (C (F) (F) F) C=C3C (F) (F) F) C=C2
Molecular Formula
C15H9F6N5OS
Molecular Weight
421.3203
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,2,3-Thiadiazole-5-carboxamide, N-[4-[3,5-bis (trifluoromethyl) -1H-pyrazol-1-yl]phenyl]-4-methyl-
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