TAK-779
TAK-779 is a potent, specific, nonpeptide CCR5 antagonist with Kd of 0.45 nM, antagonizes CCR2b to a lesser extent (27 nM) but does not affect CCR1, CCR3, or CCR4; also blocks the binding of macrophage inflammatory protein 1α and macrophage inflammatory protein 1β to the cells with an IC50 of 1.0 nM; TAK-779 displays highly potent and selective inhibition of the replication of macrophage (M) -tropic HIV-1 (Ba-L strain) in both MAGI-CCR5 cells and PBMCs with EC50 of 1.2 and 3.7 nM, respectively.HIV Infection Discontinued.
Product Specifications
CAS Number
229005-80-5
Product Name Alternative
TAK779 | TAK 799 | Takeda 779
Field of Research
Epigenetics & Chromatin
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 27 mg/mL
Smiles
CC1=CC=C (C=C1) C2=CC3=C (CCCC (=C3) C (=O) NC4=CC=C (C=C4) C[N+] (C) (C) C5CCOCC5) C=C2.[Cl-]
Molecular Formula
C33H39ClN2O2
Molecular Weight
531.1
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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