MPTP-Hydrochloride
MPTP (hydrochloride) is a prodrug to the neurotoxin MPP which causes permanent symptoms of Parkinson's disease. (In Vitro) :Pretreatment with 50 mM 4-phenylpyridine, reduces IC50 (concentration for 50% inhibition of twitch amplitude) values of MPTP from 53 to 18 mM and d-tubocurarine from 0.7 to 0.3 mM, respectively, in mouse phrenic nerve-diaphragm. (In Vivo) :The toxic effect of MPTP can be completely abolished in vivo by treatment with a monoamine oxidase inhibitor and potentiated by an inhibitor of catechol-O-methyltransferase. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models.
Product Specifications
CAS Number
23007-85-4
Product Name Alternative
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | NSC 139654
Purity
>98% (HPLC)
Solubility
DMSO: 12 mg/mL
Smiles
CN1CCC (=CC1) C2=CC=CC=C2.Cl
Molecular Formula
C12H16ClN
Molecular Weight
209.72
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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