DMX-5804
DMX-5804 (DMX5804) is a potent, selective small-molecule inhibitor of MAP4K4 with IC50 of 3 nM; displays >100-fold selectivity over GCK/MAP4K2, GLK/MAP4K3, KHS/MAP4K5 and VEGFR; rescues cell survival, mitochondrial function, and calcium cycling in hiPSC-CMs (human induced-pluripotent-stem-cell-derived cardiomyocytes), protects hiPSC-CMs with EC50 of 500 nM for cell death induced by 400 uM H2O2; reduces infarct size and ischemia-reperfusion injury in mice in mice.
Product Specifications
CAS Number
2306178-56-1
Product Name Alternative
DMX5804 | DMX 5804
Purity
>98% (HPLC)
Solubility
DMSO : 125 mg/mL 345.89 mM
Smiles
O=C1NC=NC2=C1C (C3=CC=C (OCCOC) C=C3) =CN2C4=CC=CC=C4
Molecular Formula
C21H19N3O3
Molecular Weight
361.401
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5- (4- (2-methoxyethoxy) phenyl) -7-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
Available Sizes
Frequently Asked Questions
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