Alsteropaullone
Alsteropaullone (9-Nitropaullone, NSC 705701) is a derivative of kenpaullone, ATP-competitive inhibitor of CDKs and GSK3β, inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E and Cdk5/p25 with IC50 of 35, 15, 200 and 40 nM; exhibits specific antitumor activity against Group 3 medulloblastomas, causes inhibition of cell cycle-related genes, and down-regulation of MYC; inhibits the cytosolic degradation of β-catenin to alter the canonical Wnt signaling pathway in primary axis patterning, reduces tau phosphorylation.
Product Specifications
CAS Number
237430-03-4
Product Name Alternative
9-Nitropaullone | NSC 705701
Purity
>98% (HPLC)
Smiles
O=C1NC2=CC=CC=C2C (NC3=C4C=C ([N+] ([O-]) =O) C=C3) =C4C1
Molecular Formula
C16H11N3O3
Molecular Weight
293.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
7,12-dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6 (5H) -one
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