(R) -Naproxen

An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout. (In Vitro) :l-Naproxen (30-1000 μM; 2 h) inhibits Rac1 and Cdc42 activity selectively in HeLa cells.l-Naproxen (0-300 μM; 48 h) inhibits migration of immortalized human ovarian cancer cells.l-Naproxen (300 μM; 48 h) shows activity via a COX-independent mechanism.