Doxycycline hyclate

Doxycycline Hyclate is a synthetic tetracycline derivative with similar antimicrobial activity. (In Vitro) :Doxycycline hyclate (0.01-10 μg/mL, 4 d) affects growth of glioma cells only under high concentrations.Doxycycline hyclate (0.01-10 μg/mL, 24 h) decreases MT-CO1 protein content with concentrations of 1 μg/mL and higher in SVG cells.Doxycycline hyclate (100 ng/mL, 1 μg/mL; 24 h) reduces proliferation of human cell lines.Doxycycline hyclate (0-250 μM, 72 h) inhibits cell viability of breast cancer cells . (In Vivo) :Doxycycline hyclate (oral gavage; 200 or 800 mg/kg; once daily; 3 months) reduces MMP-9 activity in untreated HT mice in a dose-dependent manner.