Clobetasol propionate
Clobetasol propionate is a anti-inflammatory corticosteroid used to treat various skin disorders. (In Vitro) :Clobetasol propionate has an IC50 of 15.6 μM for CYP3A4.Clobetasol propionate (1 μM; 24 hours) selectively inhibits CYP3A5 and does not increase the protein level of CYP3A4. Clobetasol propionate does not affect cell growth in any cell line (AsPC-1 wild-type (WT), AsPC-1CYP3A5–/– cells with CYP3A5 overexpression (“3A5–/– + 3A5OE” cells), and AsPC-1CYP3A5–/– cells with CYP3A4 overexpression (“3A5–/– + 3A4OE” cells) ) . (In Vivo) :Clobetasol propionate (applied topically; daily for 14 days) reduces the epidermal thickness of both normal and psoriatic skin in human psoriatic skin-SCID mouse transplant model topical application.
Product Specifications
CAS Number
25122-46-7
Product Name Alternative
CCl-4725 | CGP 9555 | Clobetasol 17-Propionate
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 20 mg/mL (42.82 mM) ; DMSO: 93 mg/mL (199.15 mM)
Smiles
CCC (O[C@]1 (C) [C@@H] (C) C[C@@]2 ([H]) [C@]3 ([H]) CCC4=CC (C=C[C@]4 (C) [C@@]3 (F) [C@@H] (O) C[C@]12C (CCl) =O) =O) =O
Molecular Formula
C25H32ClFO5
Molecular Weight
466.97
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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