Wiskostatin
Wiskott-Aldrich syndrome protein (WASP) and WAVE stimulate actin-related protein (Arp) 2/3-mediated actin polymerization, leading to diverse downstream effects, including the formation and remodeling of cell surface protrusions, modulation of cell migration, and intracytoplasmic propulsion of organelles and pathogens. Selective inhibitors of individual Arp2/3 activators would enable more exact dissection of WASP- and WAVE-dependent cellular pathways and are potential therapeutic targets for viral pathogenesis. Wiskostatin is a recently described chemical inhibitor that selectively inhibits neuronal WASP (N-WASP) -mediated actin polymerization in vitro.
Product Specifications
CAS Number
253449-04-6
Purity
>98% (HPLC)
Solubility
DMSO: 10 mM
Smiles
CN (C) CC (O) CN1C2=C (C=C (Br) C=C2) C2=C1C=CC (Br) =C2
Molecular Formula
C17H18Br2N2O
Molecular Weight
426.15
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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