UK-371804
UK-371804 is a potent and selective inhibitor of urokinase-type plasminogen activator (uPA) with Ki of 10 nM; displays excellent selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin) ; inhibits exogenous uPA in human chronic wound fluid with IC50 of 0.89 uM; penetrates into pig wounds and inhibits exogenous uPA activity with no adverse effect on wound healing parameters in wound model following topical delivery.Ulcer Preclinical.
Product Specifications
CAS Number
256477-09-5
Product Name Alternative
UK371804 | UK 371804
Purity
>98% (HPLC)
Solubility
DMSO: 10 mg/mL
Smiles
CC (C) (NS (=O) (C1=CC2=C (C=C1) C (Cl) =CN=C2/N=C (N) \N) =O) C (O) =O
Molecular Formula
C14H16ClN5O4S
Molecular Weight
385.82594
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Alanine, N-[[1-[ (aminoiminomethyl) amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-
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