Pelitinib
A potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM; inhibits autophosphorylation of the cytoplasmic domain of HER-2 with IC50 of 1.23 uM; shows 1-3 orders of magnitude higher IC50 value for Src, Cdk4, c-Met, Raf, and MEK/ERK; inhibits proliferation in NHEK, A431, and MDA-468 cells (IC50= 61, 125, and 260 nM, respectively) ; potently inhibits the EGFR phosphorylation in A431 xenografts, suppresses tumorigenesis in APCMin/+ mice.Lung Cancer Phase 2 Clinical.
Product Specifications
CAS Number
257933-82-7
Product Name Alternative
EKB-569 | WAY-EKB 569 | EKB569 | EKB 569
Purity
>98% (HPLC)
Solubility
DMSO: 16 mg/mL
Smiles
O=C (NC1=C (OCC) C=C2N=CC (C#N) =C (NC3=CC=C (F) C (Cl) =C3) C2=C1) /C=C/CN (C) C
Molecular Formula
C24H23ClFN5O2
Molecular Weight
467.9231
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Butenamide, N-[4-[ (3-chloro-4-fluorophenyl) amino]-3-cyano-7-ethoxy-6-quinolinyl]-4- (dimethylamino) -, (2E) -
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