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NSC 377071

NSC 377071 (NSC-377071, NSC377071, Cambendazole) is a novel ATG4B antagonist that inhibits autophagy, with no effect on mTOR and PI3K activities; directly inhibits cellular ATG4B activity induced by starvation or rapamycin and suppresses the lipidation of LC3B and autophagosome formation in response to starvation, suppresses Saos-2 osteosarcoma growth in vivo.

Product Specifications

CAS Number

26097-80-3

Product Name Alternative

NSC-377071 | NSC377071 | Cambendazole

Field of Research

Neuroscience

Purity

>98% (HPLC)

Solubility

DMSO: Soluble (< 1 mg/ml refers to the product slightly soluble or insoluble)

Smiles

O=C (OC (C) C) NC1=CC=C2C (N=C (C3=CSC=N3) N2) =C1

Molecular Formula

C14H14N4O2S

Molecular Weight

302.352

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Propan-2-yl N-[2- (1,3-thiazol-4-yl) -3H-benzimidazol-5-yl]carbamate

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