Naproxen sodium
Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively. (In Vitro) :Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively. (In Vivo) :Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM) .
Product Specifications
CAS Number
26159-34-2
Product Name Alternative
Naproxen sodium | RS 3650 | Sodium naproxen | Naproxen natrium
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Water: 50 mg/mL (198.22 mM) ; DMSO: 3 mg/mL (11.89 mM)
Smiles
O=C ([O-]) [C@@H] (C) C1=CC=C2C=C (OC) C=CC2=C1.[Na+]
Molecular Formula
C14H13NaO3
Molecular Weight
252.24
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, sodium salt, (S) -
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