Homoharringtonine
Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients with myelodysplastic syndrome . Homoharringtonine enhances the paracellular permeability of Caco-2 cell monolayers by modulating the protein expression and localization of claudin isoforms. Homoharringtonine has anti-Y and antileukemic activities, may have the potential ability to treat acute, chronic myeloid leukaemia and Gefitinib-resistant NSCLC.
Product Specifications
CAS Number
26833-87-4
Product Name Alternative
NSC 141633 | Omacetaxine Mepesuccinate
Purity
>98% (HPLC)
Solubility
Soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Smiles
COC1=C[C@@]23[C@H] (c4cc (OCO5) c5cc4CCN2CCC3) [C@@H]1OC ([C@] (O) (CCCC (C) (C) O) CC (OC) =O) =O
Molecular Formula
C29H39NO9
Molecular Weight
545.61
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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