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Homoharringtonine

Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients with myelodysplastic syndrome . Homoharringtonine enhances the paracellular permeability of Caco-2 cell monolayers by modulating the protein expression and localization of claudin isoforms. Homoharringtonine has anti-Y and antileukemic activities, may have the potential ability to treat acute, chronic myeloid leukaemia and Gefitinib-resistant NSCLC.

Product Specifications

CAS Number

26833-87-4

Product Name Alternative

NSC 141633 | Omacetaxine Mepesuccinate

Purity

>98% (HPLC)

Solubility

Soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.

Smiles

COC1=C[C@@]23[C@H] (c4cc (OCO5) c5cc4CCN2CCC3) [C@@H]1OC ([C@] (O) (CCCC (C) (C) O) CC (OC) =O) =O

Molecular Formula

C29H39NO9

Molecular Weight

545.61

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

(S) -1- ((11bS,12S,14aR) -13-methoxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl) 4-methyl 2-hydroxy-2- (4-hydroxy-4-methylpentyl) succinate

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