SB 216763
SB 216763 is a potent, selective, ATP competitive and cell permeable inhibitor GSK-3 with Ki of 9 nM (GSK-3α), equally potent for GSK-3β; displays no significant activity against a panel of 24 other protein kinases; stimulates glycogen synthesis in human liver cells and induces expression of a beta-catenin-LEF/TCF regulated reporter gene in HEK293 cells, protects both central and peripheral nervous system neurones in culture from death, activates beta-catenin-mediated transcription, and enhances the survival of CLL lymphocytes; displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis.
Product Specifications
CAS Number
280744-09-4
Product Name Alternative
SB-216763 | SB216763
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (C (C1=CC=C (Cl) C=C1Cl) =C2C3=CN (C) C4=C3C=CC=C4) NC2=O
Molecular Formula
C19H12Cl2N2O2
Molecular Weight
371.2168
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Pyrrole-2,5-dione, 3- (2,4-dichlorophenyl) -4- (1-methyl-1H-indol-3-yl) -
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