Pyrvinium pamoate
An anthelmintic effective agent for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM; binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity; inhibits Wnt signaling downstream of β-catenin, and promotes Pygopus degradation; also is a potent inhibitor of HH signaling by reducing the stability of the Gli family of transcription factors.
Product Specifications
CAS Number
3546-41-6
Product Name Alternative
Pyrvinium embonate
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 24 mg/mL
Smiles
CN (C) C1=CC2=C ([N+] (C) =C (/C=C/C3=C (C) N (C4=CC=CC=C4) C (C) =C3) C=C2) C=C1.CN (C) C5=CC6=C ([N+] (C) =C (/C=C/C7=C (C) N (C8=CC=CC=C8) C (C) =C7) C=C6) C=C5.[O-]C (C9=CC%10=C (C=CC=C%10) C (CC%11=C (O) C (C ([O-]) =O) =CC%12=C%11C=CC=C%12) =C9O) =O
Molecular Formula
C26H28N3 . 1/2 C23H14O6
Molecular Weight
575.7
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Quinolinium, 6- (dimethylamino) -2-[2- (2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl) ethenyl]-1-methyl-, 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (2:1)
Available Sizes
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