SB 525334
SB 525334 is a potent and selective inhibitor of TGF-β1 receptor (ALK5) inhibitor with IC50 of 14,5 nM, 4-fold less potent against ALK4 and inactive for ALK2, ALK3, and ALK6 (IC50>10 uM) ; blocks TGFβ1-induced phosphorylation and nuclear translocation of Smad2/3 in renal proximal tubule cells and inhibits TGFβ1-induced increases in PAI-1 and procollagen α1 mRNA expression in A498 renal epithelial carcinoma cells at 1 uM; significantly inhibits PAN-induced proteinuria in rat model of nephritis-induced renal fibrosis.
Product Specifications
CAS Number
356559-20-1
Product Name Alternative
SB-525334 | SB525334
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 46 mg/mL
Smiles
CC1=CC=CC (C2=C (C3=CC=C4N=CC=NC4=C3) N=C (C (C) (C) C) N2) =N1
Molecular Formula
C21H21N5
Molecular Weight
343.4249
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Quinoxaline, 6-[2- (1,1-dimethylethyl) -5- (6-methyl-2-pyridinyl) -1H-imidazol-4-yl]-
Available Sizes
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