2-Methoxyestradiol
2-Methoxyestradiol (2ME2; NSC-659853) is a metabolite of estradiol-17β and a novel antimitotic, antiangiogenic agent, binds to tubulin at or near the colchicine site and inhibits the polymerization of tubulin in vitro; suppresses microtubule dynamic instability in living interphase cells with mitotic IC50 of 1.2 uM, inhibits bFGF and VEGF-induced neovascularization and suppresses the growth of human breast carcinoma in mice; also downregulates hypoxia-inducible factor-1 (HIF) at the posttranscriptional level and inhibits HIF-1-induced transcriptional activation of VEGF expression.
Product Specifications
CAS Number
362-07-2
Product Name Alternative
2ME2 | NSC-659853
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 36 mg/mL; H2O: < 0.1 mg/mL
Smiles
OC1=C (OC) C=C2[C@@]3 ([H]) CC[C@]4 (C) [C@@H] (O) CC[C@@]4 ([H]) [C@]3 ([H]) CCC2=C1
Molecular Formula
C19H26O3
Molecular Weight
302.4079
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Estra-1,3,5 (10) -triene-3,17-diol, 2-methoxy-, (17.beta.) -
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