PK-11007
A 2-sulfonylpyrimidine compound that is a mild thiol alkylator with anticancer activity toward p53-compromised cells; stabilizes p53 in vitro via selective alkylation of two surface-exposed cysteines without compromising p53 DNA binding activity; also induces cell death independent of p53, but with highly elevated levels of ROS and induction of ER stress.
Product Specifications
CAS Number
38275-34-2
Product Name Alternative
PK11007
Purity
>98% (HPLC)
Solubility
DMSO : 100 mg/mL 422.60 mM
Smiles
O=C (C1=NC (S (=O) (C) =O) =NC=C1Cl) O
Molecular Formula
C6H5ClN2O4S
Molecular Weight
236.63
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-Chloro-2- (methylsulfonyl) -4-pyrimidinecarboxylic acid
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