Chelerythrine chloride
Chelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK, also inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 uM and displaces Bax from Bcl-XL; inhibits LPS-induced TNF-α level and NO production in LPS-induced murine peritoneal macrophages through selective inhibition of p38 MAPK and ERK1/2 activation; triggers apoptosis via direct action on mitochondria.
Product Specifications
CAS Number
3895-92-9
Product Name Alternative
Broussonpapyrine chloride | NSC 646662
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 3.9 mg/mL
Smiles
C[N+]1=C2C (=C3C=CC (=C (C3=C1) OC) OC) C=CC4=CC5=C (C=C42) OCO5.[Cl-]
Molecular Formula
C21H18ClNO4
Molecular Weight
383.8249
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,2-Dimethoxy-12-methyl[1,3]benzodi oxolo[5,6-c]phenanthridinium chloride
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