10058-F4
10058-F4 is a specific c-Myc inhibitor that disrupts the association between the c-Myc and Max, inhibits HL60 cell growth with IC50 of 51 uM; arrests AML cells at G0/G1 phase, downregulates c-Myc expression and upregulates CDK inhibitors p21 and p27; induces apoptosis through activation of mitochondrial pathway shown by downregulation of Bcl-2, upregulation of Bax, release of cytoplasmic cytochrome C, and cleavage of caspase 3, 7, and 9; also induces myeloid differentiation.
Product Specifications
CAS Number
403811-55-2
Product Name Alternative
10058-F4 | 10058F4 | 10058 F4
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 41 mg/mL
Smiles
O=C1NC (S/C1=C/C2=CC=C (CC) C=C2) =S
Molecular Formula
C12H11NOS2
Molecular Weight
249.3518
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-Thiazolidinone, 5-[ (4-ethylphenyl) methylene]-2-thioxo-
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