GW3965 hydrochloride
A potent, selective, orally active LXR agonist that recruits the steroid receptor coactivator 1 to human LXRα in a cell-free ligand-sensing assay with an EC50 of 125 nM; acts as a full agonist on hLXRα and hLXRβ in cell-based reporter gene assays with EC50 of 190 and 30 nM, respectively; increases expression of ABCA1 in the small intestine and peripheral macrophages in C57BL/6 mice at 10 mg/kg.Asthma Discontinued.
Product Specifications
CAS Number
405911-17-3
Product Name Alternative
GW 3965 hydrochloride | GW-3965 hydrochloride
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
Cl.OC (=O) CC1=CC=CC (OCCCN (CC (C2=CC=CC=C2) C2=CC=CC=C2) CC2=CC=CC (=C2Cl) C (F) (F) F) =C1 |c:6,18,20,25,27,33,35,42, t:4,16,23,31|
Molecular Formula
C33H32Cl2F3NO3
Molecular Weight
618.5133
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzeneacetic acid, 3-[3-[[[2-chloro-3- (trifluoromethyl) phenyl]methyl] (2,2-diphenylethyl) amino]propoxy]-, hydrochloride (1:1)
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