Sotrastaurin
A potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes; displays excellent selectivity against a broad panel of kinases (only GSK-3β IC50<1 uM) ; inhibits early T-cell activation with no general antiproliferative activity, also inhibits β2-integrin-mediated T-cell adhesiveness; prolongs rat heterotopic heart transplant survival in combination with adjunct immunosuppression agents.Blood Cancer Phase 2 Clinical.
Product Specifications
CAS Number
425637-18-9
Product Name Alternative
AEB071 | AEB 071 | AEB-071
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (C (C1=CNC2=C1C=CC=C2) =C3C4=C5C=CC=CC5=NC (N6CCN (C) CC6) =N4) NC3=O
Molecular Formula
C25H22N6O2
Molecular Weight
438.4812
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Pyrrole-2,5-dione, 3- (1H-indol-3-yl) -4-[2- (4-methyl-1-piperazinyl) -4-quinazolinyl]-
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