Cyproterone acetate

Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity. (In Vitro) :Cyproterone acetate is a partial agonist, showing agonism for the AR, with EC50 of 4.0 μM, at relatively high concentrations.Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5.Cyproterone acetate pretreatment (0,1,10, or 50 μM; 24 hours; subsequently exposed to cadmium for an additional 24 hours) resulted in a clear decrease in the sensitivity to cadmium in rat liver epithelial cell line. (In Vivo) :Adult male C57 BL/6J mice injected with 0.08 mg/g of cyproterone acetate showed an increase in cellular lipid content in the zona fasciculata and zona retjculans of the adrenal cortex.

Product Specifications

CAS Number

427-51-0

Product Name Alternative

Androcur | CPA | Cyprostat | NSC 81430 | SH 714

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

Ethanol: 10 mg/mL (23.98 mM) ; DMSO: 83 mg/mL (199.06 mM)

Smiles

CC (O[C@]1 (C (C) =O) CC[C@]2 ([H]) [C@]1 (C) CC[C@]3 ([H]) [C@@]4 (C) [C@] (C5) ([H]) [C@]5 ([H]) C (C=C4C (Cl) =C[C@@]23[H]) =O) =O

Molecular Formula

C24H29ClO4

Molecular Weight

416.94

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

(2aR,3aS,3bS,3cS,5aS,6R,8aS,8bR) -6-acetyl-10-chloro-3b,5a-dimethyl-2-oxo-2,2a,3,3a,3b,3c,4,5,5a,6,7,8,8a,8b-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-6-yl acetate