Cyproterone acetate
Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity. (In Vitro) :Cyproterone acetate is a partial agonist, showing agonism for the AR, with EC50 of 4.0 μM, at relatively high concentrations.Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5.Cyproterone acetate pretreatment (0,1,10, or 50 μM; 24 hours; subsequently exposed to cadmium for an additional 24 hours) resulted in a clear decrease in the sensitivity to cadmium in rat liver epithelial cell line. (In Vivo) :Adult male C57 BL/6J mice injected with 0.08 mg/g of cyproterone acetate showed an increase in cellular lipid content in the zona fasciculata and zona retjculans of the adrenal cortex.
Product Specifications
CAS Number
427-51-0
Product Name Alternative
Androcur | CPA | Cyprostat | NSC 81430 | SH 714
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 10 mg/mL (23.98 mM) ; DMSO: 83 mg/mL (199.06 mM)
Smiles
CC (O[C@]1 (C (C) =O) CC[C@]2 ([H]) [C@]1 (C) CC[C@]3 ([H]) [C@@]4 (C) [C@] (C5) ([H]) [C@]5 ([H]) C (C=C4C (Cl) =C[C@@]23[H]) =O) =O
Molecular Formula
C24H29ClO4
Molecular Weight
416.94
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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