Vinpocetine
Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE) . (In Vitro) :Vinpocetine (5-50 μM; 7 hours; VSMCs, HUVECs, A549 cells and RAW264.7 cells) potently inhibits TNF-α-induced NF-κB-dependent transcriptional activity in a dose-dependent manner with an approximate IC50 value of 25 μM. Vinpocetine do not have a significant effect on cell viability.Vinpocetine (50 μM; 7 hours; VSMCs, HUVECs, A549 cells and RAW264.7 cells) potently inhibits TNF-α-induced up-regulation of TNF-α, IL-1β, IL-8, MCP-1, VCAM-1, ICAM-1and MIP-2 transcripts in several cell types. (In Vivo) :Vinpocetine (2.5-10 mg/kg; intraperitoneal injection; C57BL/6 mice) potently inhibits TNF-α- or LPS-induced up-regulation of proinflammatory mediators, including TNF-α, IL-1β, and MIP-2, and decreases interstitial infiltration of polymorphonuclear leukocytes in a mouse model of TNF-α- or LPS-induced lung inflammation.
Product Specifications
CAS Number
42971-09-5
Product Name Alternative
Apovincaminic Acid ethyl ester | AY 27255 | RGH-4405
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Water: <1 mg/mL (<1 mM) ; DMSO: <1 mg/mL (<1 mM)
Smiles
O=C (C1=C[C@@] (CCC2) (CC) [C@]3 ([H]) N2CCC4=C3N1C5=C4C=CC=C5) OCC
Molecular Formula
C22H26N2O2
Molecular Weight
350.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Ethyl (41S,13aS) -13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate
Available Sizes
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