PS-1145
A specific IκB kinase (IKK) inhibitor with IC50 of 88 nM; shows no activity for JNK2, c-Src, p38α, IRAK, Lck, etc.; blocks TNFα-induced NF-κB activation in MM cells through inhibition of IκBα phosphorylation and degradation of IκBα, respectively; blocks the protective effect of IL-6 against Dex-induced apotosis, inhibits both IL-6 secretion from BMSCs triggered by MM cell adhesion and proliferation of MM cells adherent to BMSCs.
Product Specifications
CAS Number
431898-65-6
Product Name Alternative
PS1145 | PS 1145
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 43 mg/mL
Smiles
C1=CC (=CN=C1) C (=O) NC2=CC (=CC3=C2NC4=C3C=CN=C4) Cl
Molecular Formula
C17H11ClN4O
Molecular Weight
322.7484
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-Pyridinecarboxamide, N- (6-chloro-9H-pyrido[3,4-b]indol-8-yl) -
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