JNJ-7706621
A dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively; also exhibits activity towards CDK3, CDK4, and CDK6 (IC50s=50-250 nM), and no activity for Plk1 or Wee1; arrests the cell cycle at the G2-M phase; shows significant antitumor activity in tumor xenograft model.
Product Specifications
CAS Number
443797-96-4
Product Name Alternative
JNJ7706621 | JNJ 7706621
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=S (C1=CC=C (NC2=NN (C (C3=C (F) C=CC=C3F) =O) C (N) =N2) C=C1) (N) =O
Molecular Formula
C15H12F2N6O3S
Molecular Weight
394.356
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzenesulfonamide, 4-[[5-amino-1- (2,6-difluorobenzoyl) -1H-1,2,4-triazol-3-yl]amino]-
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