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BMS-345541 free base

A potent and selective IKK-2 inhibitor with IC50 of 0.3 uM; less potent for IKK-1 (IC40=4 uM) and no activity against IKK-ε; inhibits LPS-stimulated TNFα, IL-1β, IL-8, and IL-6 in THP-1 cells with IC50 of1-5 uM; has excellent pharmacokinetics in mice.

Product Specifications

CAS Number

445430-58-0

Product Name Alternative

BMS345541 (free base)

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

Cc1ccc2c (c1) n3c (cnc3c (n2) NCCN) C

Molecular Formula

C14H17N5

Molecular Weight

255.3183

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

1,2-Ethanediamine, N1- (1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl) -

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