BMS-345541 free base
A potent and selective IKK-2 inhibitor with IC50 of 0.3 uM; less potent for IKK-1 (IC40=4 uM) and no activity against IKK-ε; inhibits LPS-stimulated TNFα, IL-1β, IL-8, and IL-6 in THP-1 cells with IC50 of1-5 uM; has excellent pharmacokinetics in mice.
Product Specifications
CAS Number
445430-58-0
Product Name Alternative
BMS345541 (free base)
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
Cc1ccc2c (c1) n3c (cnc3c (n2) NCCN) C
Molecular Formula
C14H17N5
Molecular Weight
255.3183
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,2-Ethanediamine, N1- (1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl) -
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