RepSox
RepSox (E-616452, SJN-2511) is a potent, selective inhibitor of TGF-β type I receptor ALK5 with Ki of 25 nM, inhibits ALK5 autophosphorylation with IC50 of 4 nM, can replace the central reprogramming factor Sox2 by inducing nanog; specifically acts by inhibiting Tgf-β signaling, does not act by inducing Sox2 expression in the target fibroblasts; efficiently replaces transgenic Sox2 in the absence of VPA and c-Myc, as well as in both embryonic and adult fibroblasts; demonstrates effectivity at generating iPSCs.
Product Specifications
CAS Number
446859-33-2
Product Name Alternative
E-616452 | SJN 2511 | E616452 | SJN2511 | E 616452 | SJN-2511
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 52 mg/mL
Smiles
CC1=CC=CC (C2=NNC=C2C3=NC4=CC=CN=C4C=C3) =N1
Molecular Formula
C17H13N5
Molecular Weight
287.3186
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (3- (6-methylpyridin-2-yl) -1H-pyrazol-4-yl) -1,5-naphthyridine
Available Sizes
Frequently Asked Questions
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