JNJ-10229570
JNJ-10229570 (JNJ10229570) is a novel potent, selective melanocortin receptor MC1R and MC5R antagonist with binding IC50 of 270 nM and 200 nM, respectively; dose dependently inhibited the production of sebaceous lipids in cultured primary human sebocytes; Topical treatment with JNJ-10229570 of human skins transplanted onto SCID mice resulted in a marked decrease in sebum-specific lipid production, sebaceous gland's size and the expression of the sebaceous differentiation marker epithelial-membrane antigen (EMA) .Other Indication Phase 2 Discontinued.
Product Specifications
CAS Number
524923-88-4
Product Name Alternative
JNJ10229570 | JNJ 10229570
Purity
>98% (HPLC)
Solubility
DMSO : 62.5 mg/mL 160.47 mM
Smiles
COC1=CC=CC=C1C2=N/C (SN2C3=CC=CC=C3OC) =N\C4=CC=CC=C4
Molecular Formula
C22H19N3O2S
Molecular Weight
389.47
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzenamine, N- (2,3-bis (2-methoxyphenyl) -1,2,4-thiadiazol-5 (2H) -ylidene) -
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