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Pranoprofen

Pranoprofen is a PGE2 inhibitor with IC50 of 7.5 μM. (In Vitro) :Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells.Pranoprofen (5-25 μM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 μM enhances H2O2 (800 μM) -induced Dicer expression in FHC cells. (In Vivo) :Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice.Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs.

Product Specifications

CAS Number

52549-17-4

Product Name Alternative

Pyranoprofen | Y 8004

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

Ethanol: 6 mg/mL (23.5 mM) ; DMSO: 51 mg/mL (199.78 mM)

Smiles

CC (C1=CC (CC2=CC=CN=C2O3) =C3C=C1) C (O) =O

Molecular Formula

C15H13NO3

Molecular Weight

255.28

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

2- (5H-Chromeno[2,3-b]pyridin-7-yl) propanoic acid

Available Sizes

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