Pranoprofen
Pranoprofen is a PGE2 inhibitor with IC50 of 7.5 μM. (In Vitro) :Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells.Pranoprofen (5-25 μM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 μM enhances H2O2 (800 μM) -induced Dicer expression in FHC cells. (In Vivo) :Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice.Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs.
Product Specifications
CAS Number
52549-17-4
Product Name Alternative
Pyranoprofen | Y 8004
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 6 mg/mL (23.5 mM) ; DMSO: 51 mg/mL (199.78 mM)
Smiles
CC (C1=CC (CC2=CC=CN=C2O3) =C3C=C1) C (O) =O
Molecular Formula
C15H13NO3
Molecular Weight
255.28
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (5H-Chromeno[2,3-b]pyridin-7-yl) propanoic acid
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