Kinetin

Kinetin is a type of cytokinin, a class of plant hormone that promotes cell division. (In Vitro) :Kinetin (N6-furfuryladenine) shows to have a direct effect on superoxide dismutase activity in plants; prevent oxidation of unsaturated acids in plant membranes; slow down development and aging in insects, by reducing their fecundity and increasing the specific activity of catalase; and delay the onset of many age-related characteristics that appear in normal human skin fibroblasts undergoing aging in vitro. Kinetin (70-150 μM) markedly suppressed hydroxyl radical formation by about 41% and 76%, respectively.The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured familial dysautonomia (FD) cells. (In Vivo) :Kinetin (N6-furfuryladenine) (2-6 mg/kg; injection into the tail vein) effectively prevents ADP-induced acute pulmonary thrombosis in mice.Subjects received 23.5 mg/kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant.