APR-246
APR-246 (PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity, acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation; also restores the pro-apoptotic function to mutant TAp63γ and TAp73β in tumor cells but has less effect on TAp73α; induces mutant p53-dependent mitochondria-mediated apoptosis through activation of caspase-2 with subsequent cytochrome c release and further activation of downstream caspase-9 and caspase-3; inhibits tumor xenograft growth in vivo.Ovarian Cancer Phase 2 Clinical.
Product Specifications
CAS Number
5291-32-7
Product Name Alternative
PRIMA-1MET
Purity
>98% (HPLC)
Solubility
DMSO: 20mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C1C (COC) (CO) N2CCC1CC2
Molecular Formula
C10H17NO3
Molecular Weight
199.25
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (Hydroxymethyl) -2- (methoxymethyl) -1-azabicyclo[2.2.2]octan-3-one
Available Sizes
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