HDACi-4b
A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells; reverses FXN silencing in primary lymphocytes from individuals with Friedreich's ataxia; directly affects the histones associated with FXN, increasing acetylation at particular lysine residues on histones H3 and H4 (H3K14, H4K5 and H4K12) ; significantly improves motor performance, overall appearance, and body weight in an HD mouse model.
Product Specifications
CAS Number
537034-15-4
Product Name Alternative
NKL22 | NKL-22
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 29 mg/mL
Smiles
O=C (NC1=CC=CC=C1N) CCCCCC (NC2=CC=CC=C2) =O
Molecular Formula
C19H23N3O2
Molecular Weight
325.4048
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Heptanediamide, N1- (2-aminophenyl) -N7-phenyl-
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