Tubacin
Tubacin is a potent, selective inhibitor of class II histone deacetylase 6 (HDAC6) with IC50 of 4 nM, displays> 300-fold selectivity against all other HDAC isoforms; induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures, iinhibits proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma; also suppresses proliferation and induces apoptosis of AML cells.
Product Specifications
CAS Number
537049-40-4
Product Name Alternative
Tubacin
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC1=CC=C ([C@@H]2O[C@H] (C3=CC=C (CO) C=C3) C[C@H] (CSC4=NC (C5=CC=CC=C5) =C (C6=CC=CC=C6) O4) O2) C=C1) CCCCCCC (NO) =O
Molecular Formula
C41H43N3O7S
Molecular Weight
721.861
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Octanediamide, N1-[4-[ (2R,4R,6S) -4-[[ (4,5-diphenyl-2-oxazolyl) thio]methyl]-6-[4- (hydroxymethyl) phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-, rel-
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