UF-010
A potent and selective inhibitor of class I HDACs with IC50s of 0.5/0.1/0.06/1.5/9.1/15.3/44.5 uM for HDAC1/2/3/8/6/10/11 respectively; shows no effect on HDAC4/5/7/9 (>100 uM) ; induces the accumulation of protein acetylation and inhibits proliferation of NCI-60 panel of cancer cell lines (mean GI50=2.94 uM) ; a competitive with a fast-on/slow-off HDAC-binding mechanism.
Product Specifications
CAS Number
537672-41-6
Product Name Alternative
UF010 | UF 010
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NNCCCC) C1=CC=C (Br) C=C1
Molecular Formula
C11H15BrN2O
Molecular Weight
271.1536
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzoic acid, 4-bromo-, 2-butylhydrazide
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